In the third volume of the encyclopedic publication "Medicinal Plants of Turkmenistan", the President of Turkmenistan Gurbanguly Berdimuhamedov gives a biological characterization of Turkmen mandrake (Mandragora turcomanica). Turkmen mandrake belongs to the nightshade family, height 20-40 cm, leaves in the form of rosettes with a diameter of 160 cm, the lower ones of which are 80 cm long, and the upper ones are shorter. Valuable qualities of Turkmen mandrake are frost resistance and a long growing season, which allows to consider mandrake a promising vegetable plant for selection work. The medicinal properties of this plant have been known since ancient times. Mandragora was used as a sleeping pill, narcotic drug. Other properties of this plant are described: emetic, diuretic, hemostatic. Information is presented about the use of mandrake in the treatment of acute pain and cramps in the eyes, solid tumors and purulent ulcers, and poisonous insect bites. Leaves are applied to bruises, roots – to furuncles, to pain points in joint pain [1, 5].

The aim of the work is to determine the antimicrobial activity of tincture prepared from the leaves of Turkmen mandrake, to identify the possibility of using the preparation in practice.